Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …

The family of ten-eleven translocation dioxygenases (TETs) consists of TET1, TET2, and
TET3. Although all TETs are expressed in hematopoietic tissues, only TET2 is commonly …

Cancer is recognized as a preeminent factor of the world's mortality. Although various
modalities have been designed to cure this life-threatening ailment, a significant impediment …

There is an ongoing shift in demographics such that older persons will outnumber young
persons in the coming years, and with it age-associated tissue attrition and increased …

Juvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative neoplasm of
childhood. The molecular hallmark of JMML is hyperactivation of the Ras/MAPK pathway …

Activating mutations of FLT3 contribute to deregulated hematopoietic stem and progenitor
cell (HSC/Ps) growth and survival in patients with acute myeloid leukemia (AML), leading to …

Hematopoietic stem cells (HSCs) produce all blood cells throughout the life of the organism.
However, the high self-renewal and longevity of HSCs predispose them to accumulate …

Hematopoietic stem cell transplantation (HSCT) is a critical treatment modality for many
hematological and non-hematological diseases that is being extended to treat older …

Genome-wide CRISPR screens have been extremely useful in identifying therapeutic
targets in diverse cancers by defining genes that are essential for malignant growth …

Hematopoiesis is dynamically controlled by an epigenetic landscape that regulates gene
transcription. Ten-eleven translocation 2 (TET2) is a Fe 2+ and α-ketoglutarate (α-KG) …