Autoimmune diseases are characterized by dysfunctional immune systems that
misrecognize self as non‐self and cause tissue destruction. Several cell types have been …

Recent advances in our understanding of the pathogenesis of type 1 diabetes have
occurred in all steps of the disease. This review outlines the pathogenic mechanisms utilized …

B cell-deficient nonobese diabetic (NOD) mice are protected from the development of
spontaneous autoimmune diabetes, suggesting a requisite role for Ag presentation by B …

The ability of the adult pancreas to generate new insulin (β) cells has been controversial
because of difficulties in unequivocally identifying the precursor population. We recently …

Islet cell ontogeny will define adult β-cell mass and will consist of a balance of islet cell birth
and death. We have investigated the ontogeny of factors that may be related to …

The nonobese diabetic (NOD) mouse spontaneously develops autoimmune insulin-
dependent diabetes mellitus (IDDM) and serves as an animal model for human type I …

Activating and inhibitory CD94/NKG2 receptors regulate CTL responses by altering TCR
signaling, thus modifying antigen activation thresholds set during thymic selection. To …

Major histocompatibility complex (MHC) class II alleles HLA-DQ8 and the mouse homologue
I-Ag7 lacking a canonical aspartic acid residue at position β57 are associated with coeliac …

Spondyloarthropathies constitute a group of autoimmune diseases of special interest
because of their tight association with the MHC class I molecule HLA-B27 and the bacterial …

The mechanisms responsible for initiating autoimmune diabetes remain obscure. Here, we
describe a method for identifying both the α-and β-chains of the T cell receptor (TCR) from …