Molecular targets of manganese-induced neurotoxicity: A five-year update

AA Tinkov, MMB Paoliello, AN Mazilina… - International journal of …, 2021 - mdpi.com
Understanding of the immediate mechanisms of Mn-induced neurotoxicity is rapidly
evolving. We seek to provide a summary of recent findings in the field, with an emphasis to …

Emerging technologies and their impact on regulatory science

E Anklam, MI Bahl, R Ball, RD Beger… - Experimental …, 2022 - journals.sagepub.com
There is an evolution and increasing need for the utilization of emerging cellular, molecular
and in silico technologies and novel approaches for safety assessment of food, drugs, and …

[HTML][HTML] Whole-brain mapping of increased manganese levels in welders and its association with exposure and motor function

H Monsivais, CL Yeh, A Edmondson, R Harold… - NeuroImage, 2024 - Elsevier
Although manganese (Mn) is a trace metal essential for humans, chronic exposure to Mn
can cause accumulation of this metal ion in the brain leading to an increased risk of …

Higher r2* in the red nucleus is associated with lead exposure in an asymptomatic welder cohort

JM Prado-Rico, EY Lee, EW Wang… - Toxicological …, 2022 - academic.oup.com
Lead is a nonessential metal and may be a coexposure in welding fumes. Preclinical data
indicate lead may affect iron regulation. The current study investigated blood lead …

[HTML][HTML] Welding techniques and manganese concentrations in blood and brain: Results from the WELDFUMES study

P Thunberg, G Wastensson, G Lidén, M Adjeiwaah… - Neurotoxicology, 2024 - Elsevier
This study used whole-brain mapping to investigate the effect of different welding processes
on manganese (Mn) accumulation in the brain. Exposure measurements were performed at …

Magnetic Resonance Imaging and Manganism: A Narrative Review and Laboratory Recommendations

M Majewski, K Piwko, M Ordak, E Muszynska… - Journal of Clinical …, 2024 - mdpi.com
In recent years, a series of articles has been published concerning magnetic resonance
imaging (MRI) studies in a group of patients exposed to manganism, specifically factory …

Gray matter morphometric biomarkers for distinguishing manganese-exposed welders from healthy adults revealed by source-based morphometry

J Wu, Q Zhang, M Ma, Y Dong, P Sun, M Gao, P Liu… - NeuroToxicology, 2024 - Elsevier
Background Chronic overexposure to manganese (Mn) may result in neurotoxicity, which is
characterized by motor and cognitive dysfunctions. This study aimed to utilize multivariate …

Magnetic resonance imaging T1 indices of the brain as biomarkers of inhaled manganese exposure

N Jensen, R Terrell, S Ramoju… - Critical Reviews in …, 2022 - Taylor & Francis
Excessive exposure to manganese (Mn) is linked to its accumulation in the brain and
adverse neurological effects. Paramagnetic properties of Mn allow the use of magnetic …

Higher hippocampal diffusivity values in welders are associated with greater R2* in the red nucleus and lower psychomotor performance

EY Lee, J Kim, JM Prado-Rico, G Du, MM Lewis… - Neurotoxicology, 2023 - Elsevier
Introduction Chronic excessive welding exposure may be related to higher metal
accumulation and structural differences in different subcortical structures. We examined how …

Neurotoxicology and behavior

WK Boyes, E Bingham, B Cohrssen… - Patty's Toxicology, 5th …, 2012 - books.google.com
Neurotoxicity is important to consider as a component of occupational and environmental
safety and health programs. The access to a workplace and environment that is free of …