Osteoarthritis is a chronic degenerative disorder of the joint and represents one of the most
common diseases worldwide. Its prevalence and severity are increasing owing to aging of …

Biomaterials are employed in the fields of tissue engineering and regenerative medicine
(TERM) in order to enhance the regeneration or replacement of tissue function and/or …

Biological tissues comprise a spatially complex structure, composition and organization at
the microscale, named the microstructure. Given the close structure-function relationships in …

To date, the combination of histological sectioning, staining, and microscopic assessment of
the 2D sections is still the golden standard for structural and compositional analysis of …

Osteoarthritis causes debilitating pain and disability, resulting in a considerable
socioeconomic burden, yet no drugs are available that prevent disease onset or …

The main challenge in tissue engineering consists in understanding and controlling the
growth process of in vitro cultured neotissues toward obtaining functional tissues …

For three-dimensional bio-printed cell-laden hydrogel tissue constructs, the well-designed
internal porous geometry is tailored to obtain the desired structural and cellular properties …

Objective Mouse articular cartilage (AC) is mostly assessed by histopathology and its
mechanics is poorly characterised. In this study:(1) we developed non-destructive imaging …

Osteoarthritis (OA) is characterized by critical alterations of the subchondral bone
microstructure, besides the well‐known cartilaginous changes. Clinical computed …

Mouse models of osteoarthritis (OA) are commonly used to study the disease's pathogenesis
and efficacy of potential treatments. However, measuring the biochemical and mechanical …