The chemistry and biological activities of peptides from amphibian skin secretions

X Xu, R Lai - Chemical reviews, 2015 - ACS Publications
Amphibian skin is directly exposed to different environments. Amphibians interact with
environmental factors including microorganisms, parasites, predators, and physical factors …

[HTML][HTML] Macrophages as host, effector and immunoregulatory cells in leishmaniasis: Impact of tissue micro-environment and metabolism

C Bogdan - Cytokine: X, 2020 - Elsevier
Leishmania are protozoan parasites that predominantly reside in myeloid cells within their
mammalian hosts. Monocytes and macrophages play a central role in the pathogenesis of …

[HTML][HTML] Structure, membrane orientation, mechanism, and function of pexiganan—a highly potent antimicrobial peptide designed from magainin

LM Gottler, A Ramamoorthy - Biochimica et Biophysica Acta (BBA) …, 2009 - Elsevier
The growing problem of bacterial resistance to conventional antibiotic compounds and the
need for new antibiotics have stimulated interest in the development of antimicrobial …

Recent applications of retro-inverso peptides

N Doti, M Mardirossian, A Sandomenico… - International Journal of …, 2021 - mdpi.com
Natural and de novo designed peptides are gaining an ever-growing interest as drugs
against several diseases. Their use is however limited by the intrinsic low bioavailability and …

Impact of Leishmania metalloprotease GP63 on macrophage signaling

A Isnard, MT Shio, M Olivier - Frontiers in cellular and infection …, 2012 - frontiersin.org
The intramacrophage protozoan parasites of Leishmania genus have developed
sophisticated ways to subvert the innate immune response permitting their infection and …

Leishmaniasis: current treatment and prospects for new drugs and vaccines

L Kedzierski, A Sakthianandeswaren… - Current medicinal …, 2009 - ingentaconnect.com
Leishmaniasis is a disease that ranges in severity from skin lesions to serious disfigurement
and fatal systemic infection. WHO estimates that the disease results in 2 million new cases a …

Deception and Manipulation: The Arms of Leishmania, a Successful Parasite

P Cecílio, B Pérez-Cabezas, N Santarém… - Frontiers in …, 2014 - frontiersin.org
Leishmania spp. are intracellular parasitic protozoa responsible for a group of neglected
tropical diseases, endemic in 98 countries around the world, called leishmaniasis. These …

Antimicrobial peptide action on parasites

M Torrent, D Pulido, L Rivas, D Andreu - Current drug targets, 2012 - ingentaconnect.com
Diseases caused by protozoan parasites can pose a severe thread to human health and are
behind some serious neglected tropical diseases like malaria and leishmaniasis. Though …

The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation

M Hallé, MA Gomez, M Stuible, H Shimizu… - Journal of Biological …, 2009 - ASBMB
The Leishmania parasite is a widespread disease threat in tropical areas, causing
symptoms ranging from skin lesions to death. Leishmania parasites typically invade …

[HTML][HTML] Proteomic analysis of exosomes derived from procyclic and metacyclic-like cultured Leishmania infantum chagasi

DM Forrest, M Batista, FK Marchini, AJ Tempone… - Journal of …, 2020 - Elsevier
Leishmania infantum chagasi is the primary etiological agent of visceral leishmaniasis in
Latin America, a lethal disease that afflicts hundreds of thousands of people worldwide …