Strategies for 3D bioprinting of spheroids: A comprehensive review
Biofabricated tissues have found numerous applications in tissue engineering and
regenerative medicine in addition to the promotion of disease modeling and drug …
regenerative medicine in addition to the promotion of disease modeling and drug …
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation
Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …
new era for disease modeling and drug discovery. Over the past decade, significant …
Microfluidic organs-on-chips
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …
methods that contains continuously perfused chambers inhabited by living cells arranged to …
Long-term culture of genome-stable bipotent stem cells from adult human liver
Despite the enormous replication potential of the human liver, there are currently no culture
systems available that sustain hepatocyte replication and/or function in vitro. We have …
systems available that sustain hepatocyte replication and/or function in vitro. We have …
A liver-on-a-chip platform with bioprinted hepatic spheroids
The inadequacy of animal models in correctly predicting drug and biothreat agent toxicity in
humans has resulted in a pressing need for in vitro models that can recreate the in vivo …
humans has resulted in a pressing need for in vitro models that can recreate the in vivo …
[HTML][HTML] Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes
M Baxter, S Withey, S Harrison, CP Segeritz… - Journal of …, 2015 - Elsevier
Background & Aims Hepatocyte-like cells (HLCs), differentiated from pluripotent stem cells
by the use of soluble factors, can model human liver function and toxicity. However, at …
by the use of soluble factors, can model human liver function and toxicity. However, at …
Liver 'organ on a chip'
The liver plays critical roles in both homeostasis and pathology. It is the major site of drug
metabolism in the body and, as such, a common target for drug-induced toxicity and is …
metabolism in the body and, as such, a common target for drug-induced toxicity and is …
[HTML][HTML] In vitro expansion of primary human hepatocytes with efficient liver repopulation capacity
K Zhang, L Zhang, W Liu, X Ma, J Cen, Z Sun, C Wang… - Cell stem cell, 2018 - cell.com
Transplantation of human hepatocytes (HHs) holds significant potential for treating liver
diseases. However, the supply of transplantable HHs is severely constrained by limited …
diseases. However, the supply of transplantable HHs is severely constrained by limited …
[HTML][HTML] Organoid models of human gastrointestinal development and disease
We have greatly advanced our ability to grow a diverse range of tissue-derived and
pluripotent stem cell–derived gastrointestinal (GI) tissues in vitro. These systems, broadly …
pluripotent stem cell–derived gastrointestinal (GI) tissues in vitro. These systems, broadly …
Conversion of terminally committed hepatocytes to culturable bipotent progenitor cells with regenerative capacity
T Katsuda, M Kawamata, K Hagiwara, R Takahashi… - Cell stem cell, 2017 - cell.com
A challenge for advancing approaches to liver regeneration is loss of functional
differentiation capacity when hepatocyte progenitors are maintained in culture. Recent …
differentiation capacity when hepatocyte progenitors are maintained in culture. Recent …