Pancreatic cancer is an aggressive cancer with a dismal prognosis. This is due to the
difficulty to detect the disease at an early and curable stage. In addition, only limited …

Tumour-associated KRAS mutations are the most prevalent in the three RAS-family isoforms
and involve many different amino-acids. Therefore, molecules able to interfere with mutant …

Inhibiting the RAS oncogenic protein has largely been through targeting the switch regions
that interact with signalling effector proteins. Here, we report designed ankyrin repeat …

Abstract The Wnt receptor Frizzled3 (FZD3) is important for brain axonal development and
cancer progression. We report structures of FZD3 in complex with extracellular and …

Cytidine deaminase (CDA) converts cytidine and deoxycytidine into uridine and
deoxyuridine as part of the pyrimidine salvage pathway. Elevated levels of CDA are found in …

The Ras subfamily of small GTPases is mutated in∼ 30% of human cancers and represents
compelling yet challenging anticancer drug targets owing to their flat protein surface. We …

Genetically encoded Ras biosensors have been instrumental in illuminating the
spatiotemporal dynamics of Ras activity since the beginning of the imaging revolution of the …

TDP1 removes transcription-blocking topoisomerase I cleavage complexes (TOP1ccs), and
its inactivating H493R mutation causes the neurodegenerative syndrome SCAN1. However …

Intracellular antibodies are tools that can be used directly for target validation by interfering
with properties like protein-protein interactions. An alternative use of intracellular antibodies …

Targeted protein degradation (TPD) strategy harnesses the ubiquitin-proteasome system
(UPS) to degrade a protein of interest (POI) by bringing it into proximity with an E3 ubiquitin …