Evolution of microRNA diversity and regulation in animals

E Berezikov - Nature Reviews Genetics, 2011 - nature.com
In the past decade, microRNAs (miRNAs) have been uncovered as key regulators of gene
expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic …

microRNA functions

N Bushati, SM Cohen - Annu. Rev. Cell Dev. Biol., 2007 - annualreviews.org
microRNAs (miRNAs) are small noncoding RNAs that play important roles in
posttranscriptional gene regulation. In animal cells, miRNAs regulate their targets by …

The diverse functions of microRNAs in animal development and disease

WP Kloosterman, RHA Plasterk - Developmental cell, 2006 - cell.com
MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization
of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in …

The evolution of gene regulation by transcription factors and microRNAs

K Chen, N Rajewsky - Nature Reviews Genetics, 2007 - nature.com
Abstract Changes in the patterns of gene expression are widely believed to underlie many of
the phenotypic differences within and between species. Although much emphasis has been …

Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury

OF Laterza, L Lim, PW Garrett-Engele… - Clinical …, 2009 - academic.oup.com
Background: MicroRNAs (miRNAs) are endogenous, small noncoding RNAs. Because of
their size, abundance, tissue specificity, and relative stability in plasma, miRNAs hold …

Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal circulation via exosomes

SS Luo, O Ishibashi, G Ishikawa, T Ishikawa… - Biology of …, 2009 - academic.oup.com
In this study, we performed small RNA library sequencing using human placental tissues to
identify placenta-specific miRNAs. We also tested the hypothesis that human chorionic villi …

A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia

X Liu, Y Cheng, S Zhang, Y Lin, J Yang… - Circulation …, 2009 - Am Heart Assoc
MicroRNAs (miRNAs) comprise a novel class of endogenous, small, noncoding RNAs that
negatively regulate gene expression. Functionally, an individual miRNA is as important as a …

MicroRNA expression in the adult mouse central nervous system

M Bak, A Silahtaroglu, M Møller, M Christensen… - Rna, 2008 - rnajournal.cshlp.org
microRNAs are∼ 22 nucleotide endogenous noncoding RNAs that post-transcriptionally
repress expression of protein-coding genes by base-pairing with the 3′-untranslated …

Genomic organization of microRNAs

AF Olena, JG Patton - Journal of cellular physiology, 2010 - Wiley Online Library
Abstract microRNAs (miRNAs) are small (∼ 22 nt) noncoding RNAs that have been shown
to regulate gene expression post‐transcriptionally. They function by pairing with the 3 …

The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases

JR Finnerty, WX Wang, SS Hébert, BR Wilfred… - Journal of molecular …, 2010 - Elsevier
The miR-15/107 group of microRNA (miRNA) gene is increasingly appreciated to serve key
functions in humans. These miRNAs regulate gene expression involved in cell division …