Podophyllotoxin: history, recent advances and future prospects

Z Shah, UF Gohar, I Jamshed, A Mushtaq, H Mukhtar… - Biomolecules, 2021 - mdpi.com
Podophyllotoxin, along with its various derivatives and congeners are widely recognized as
broad-spectrum pharmacologically active compounds. Etoposide, for instance, is the …

Biotechnological approaches for producing aryltetralin lignans from Linum species

S Malik, O Biba, J Grúz, RRJ Arroo, M Strnad - Phytochemistry reviews, 2014 - Springer
The genus Linum includes more than 230 globally distributed species, which have attracted
great interest as they grow rapidly and are already sources of commercially important …

Immunomodulatory activities of various medicinal plant extracts: effects on human lymphocytes apoptosis

Z Amirghofran, M Bahmani, A Azadmehr… - Immunological …, 2009 - Taylor & Francis
Plant extracts have been widely evaluated for biological properties. In the present study
extracts of several native plants in Iran was investigated for their possible …

Proteins differentially expressed in elicited cell suspension culture of Podophyllum hexandrum with enhanced podophyllotoxin content

D Bhattacharyya, R Sinha, S Ghanta, A Chakraborty… - Proteome science, 2012 - Springer
Background Podophyllotoxin (PTOX), the precursor for semi-synthesis of cancer
therapeutics like etoposide, teniposide and etophos, is primarily obtained from an …

De novo transcriptome analysis using 454 pyrosequencing of the Himalayan Mayapple, Podophyllum hexandrum

D Bhattacharyya, R Sinha, S Hazra, R Datta… - BMC genomics, 2013 - Springer
Abstract Background The Himalayan or Indian Mayapple (Podophyllum hexandrum Royle)
produces podophyllotoxin, which is used in the production of semisynthetic anticancer …

Induction of apoptosis in leukemia cell lines by Linum persicum and Euphorbia cheiradenia

Z Amirghofran, M Bahmani, A Azadmehr… - Journal of cancer …, 2006 - Springer
Purpose: In the present study two medicinal herbs Linum persicum and Euphorbia
cheiradenia that are native to Iran were tested for their possible anticancer effect and …

Optimization of podophyllotoxin extraction method from Linum album cell cultures

M Yousefzadi, M Sharifi, NA Chashmi… - Pharmaceutical …, 2010 - Taylor & Francis
Context: Suspension cultures of Linum album Kotschy ex Boiss.(Linaceae) accumulate
podophyllotoxin (an anticancer agent) and could therefore serve as an alternative source of …

[HTML][HTML] Endophytes producing podophyllotoxin from Podophyllum sp. and other plants: A review on isolation, extraction and bottlenecks

D Biswas, P Biswas, S Nandy, A Mukherjee… - South African Journal of …, 2020 - Elsevier
Investigation on the secondary metabolites of endophytic organisms colonized within plant
body is now giving emphasis on the medicinal properties of those products aiming to the …

Green and efficient extraction of podophyllotoxin from Sinopodophyllum hexandrum by optimized subcritical water extraction combined with macroporous resin …

Y Wang, G Zhang, XF Chi, S Chen - Industrial Crops and Products, 2018 - Elsevier
Sinopodophyllum hexandrum is an important traditional Tibetan medicinal plant with great
development potential in pharmaceutical industry because of the presence of major …

Methyl Jasmonate Regulates Podophyllotoxin Accumulation in Podophyllum hexandrum by Altering the ROS-Responsive Podophyllotoxin Pathway Gene Expression …

S Hazra, D Bhattacharyya… - Frontiers in Plant …, 2017 - frontiersin.org
Podophylloxin (ptox), primarily obtained from Podophyllum hexandrum, is the precursor for
semi-synthetic anticancer drugs viz. etoposide, etopophos, and teniposide. Previous studies …