Recent advances in biocatalysis with chemical modification and expanded amino acid alphabet

AD Pagar, MD Patil, DT Flood, TH Yoo… - Chemical …, 2021 - ACS Publications
The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …

[HTML][HTML] Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

B Wiltschi, T Cernava, A Dennig, MG Casas… - Biotechnology …, 2020 - Elsevier
Competitive sustainable production in industry demands new and better biocatalysts,
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …

Biocatalysis with unnatural amino acids: enzymology meets xenobiology

F Agostini, JS Völler, B Koksch… - Angewandte Chemie …, 2017 - Wiley Online Library
The goal of xenobiology is to design biological systems endowed with unusual biochemical
functions, whereas enzymology concerns the study of enzymes, the workhorses of …

Chemical modification of enzymes to improve biocatalytic performance

P Giri, AD Pagar, MD Patil, H Yun - Biotechnology Advances, 2021 - Elsevier
Improvement in intrinsic enzymatic features is in many instances a prerequisite for the
scalable applicability of many industrially important biocatalysts. To this end, various …

Going the distance: long-range conductivity in protein and peptide bioelectronic materials

NL Ing, MY El-Naggar… - The Journal of Physical …, 2018 - ACS Publications
Bioelectronic materials interface biomolecules, cells, organs, or organisms with electronic
devices, and they represent an active and growing field of materials research. Protein and …

A review of enzyme design in catalytic stability by artificial intelligence

Y Ming, W Wang, R Yin, M Zeng, L Tang… - Briefings in …, 2023 - academic.oup.com
The design of enzyme catalytic stability is of great significance in medicine and industry.
However, traditional methods are time-consuming and costly. Hence, a growing number of …

Low-calorie bulk sweeteners: Recent advances in physical benefits, applications, and bioproduction

J Li, Q Dai, Y Zhu, W Xu, W Zhang… - Critical Reviews in …, 2024 - Taylor & Francis
At present, with the continuous improvement of living standards, people are paying
increasing attention to dietary nutrition and health. Low sugar and low energy consumption …

Non-canonical amino acid labeling in proteomics and biotechnology

AM Saleh, KM Wilding, S Calve, BC Bundy… - Journal of Biological …, 2019 - Springer
Metabolic labeling of proteins with non-canonical amino acids (ncAAs) provides unique
bioorthogonal chemical groups during de novo synthesis by taking advantage of both …

Adaptive evolution of genomically recoded Escherichia coli

TM Wannier, AM Kunjapur, DP Rice… - Proceedings of the …, 2018 - National Acad Sciences
Efforts are underway to construct several recoded genomes anticipated to exhibit multivirus
resistance, enhanced nonstandard amino acid (nsAA) incorporation, and capability for …

Harnessing L-arabinose isomerase for biological production of D-tagatose: Recent advances and its applications

Y Ravikumar, LN Ponpandian, G Zhang, J Yun… - Trends in Food Science & …, 2021 - Elsevier
Background d-tagatose is regarded as one of the most valuable rare sugars in the current
market and its biotechnological ways of production is a very hot topic as of today. As a …