Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …

Neurological and mental illnesses account for a considerable proportion of the global
burden of disease. Exercise has many beneficial effects on brain health, contributing to …

Obesity is associated with a chronic state of low-grade inflammation and progressive tissue
infiltration by immune cells and increased expression of inflammatory cytokines. It is …

Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …

Exercise mimetics are a proposed class of therapeutics that specifically mimic or enhance
the therapeutic effects of exercise. Increased physical activity has demonstrated positive …

IL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or
infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune …

Objective Although inflammation is increasingly implicated in psychiatric disorders, less is
known about its role in anorexia nervosa (AN), an illness with low body mass index (BMI) …

When challenged with a variety of inflammatory threats, multiple systems across the body
undergo physiological responses to promote defense and survival. The constellation of …

The hypothalamus is one of the master regulators of various physiological processes,
including energy balance and nutrient metabolism. These regulatory functions are mediated …

High-intensity exercise suppresses appetite partly through changes in peripheral appetite-
regulating hormones. Lactate and IL-6 mediate the release of these hormones in animal/cell …