Added by telomerase, arrays of TTAGGG repeats specify the ends of human chromosomes.
A complex formed by six telomere-specific proteins associates with this sequence and …

Telomeres play a central role in cell fate and aging by adjusting the cellular response to
stress and growth stimulation on the basis of previous cell divisions and DNA damage. At …

Most human somatic cells can undergo only a limited number of population doublings in
vitro. This exhaustion of proliferative potential, called senescence, can be triggered when …

Cellular senescence can be triggered by telomere shortening as well as a variety of stresses
and signaling imbalances. We used multiparameter single-cell detection methods to …

The DNA double-strand break (DSB) is the principle cytotoxic lesion for ionizing radiation
and radio-mimetic chemicals but can also be caused by mechanical stress on chromosomes …

Fusion genes that are caused by chromosome translocations have been recognized for
several decades as drivers of deregulated cell growth in certain types of cancer. In recent …

Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …

Aging can be defined as progressive functional decline and increasing mortality over time.
Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates …

Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When
telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA …

▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …