Notch signalling is involved in many aspects of cancer biology, including angiogenesis,
tumour immunity and the maintenance of cancer stem-like cells. In addition, Notch can …

During the past decade, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. Although the origin and plasticity of these cells remain controversial, tumour …

Radiotherapy represents the most effective nonsurgical treatments for gliomas. However,
gliomas are highly radioresistant and recurrence is nearly universal. Results from our …

For the last few decades, while significant improvements have been achieved in cancer
therapy, this family of diseases is still considered one of the deadliest threats to human …

T cells are the key mediators in cell-mediated immunity. Their development and maturation
involve a complex variety of interactions with nonlymphoid cell products and receptors …

The cellular heterogeneity of neoplasms has been at the center of considerable interest
since the “cancer stem cell hypothesis”, originally formulated for hematologic malignancies …

A role for Notch signaling in human breast cancer has been suggested by both the
development of adenocarcinomas in the murine mammary gland following pathway …

The Notch pathway, although originally identified in fruit flies, is now among the most heavily
studied in mammalian biology. In mice, loss-of-function and gain-of-function work has …

Members of the Notch family of transmembrane receptors play an important role in cell fate
determination. Over the past decade, a role for Notch in the pathogenesis of hematologic …

Mutations in the phosphatase and tensin homolog (PTEN) gene leading to PTEN protein
deletion and subsequent activation of the PI3K/Akt signaling pathway are common in …