Despite the substantial progress achieved in the characterization of cytochrome P450 (CYP)-
based resistance mechanisms in mosquitoes, a number of questions remain unanswered …

Monitoring local mosquito populations for insecticide resistance is critical for effective vector-
borne disease control. However, widely used phenotypic assays, which are designed to …

Cytochrome P450 mediated metabolism is a well-known mechanism of insecticide
resistance. However, to what extent qualitative or quantitative changes are responsible for …

Studies of insecticide resistance provide insights into the capacity of populations to show
rapid evolutionary responses to contemporary selection. Malaria control remains heavily …

Signatures of positive selection in the genome are a characteristic mark of adaptation that
can reveal an ongoing, recent, or ancient response to environmental change throughout the …

Simple Summary Malaria is one of the most severe life-threatening human vector-borne
diseases worldwide today, leading to high mortality. Children under the age of five and …

Background The massive scale-up of long-lasting insecticidal nets (LLIN) has led to a major
reduction in malaria burden in many sub-Saharan African (SSA) countries. The World Health …

Adaptive mutations can cause drug resistance in cancers and pathogens, and increase the
tolerance of agricultural pests and diseases to chemical treatment. When and how adaptive …

Genetic mapping has been widely employed to search for genes linked to phenotypes/traits
of interest. Because of the ease of maintaining rodent malaria parasites in laboratory mice …

Background The emergence of insecticide resistance is a major threat to malaria control
programmes in Africa, with many different factors contributing to insecticide resistance in its …