The existence of the neural control of mast cell functions has long been proposed. Mast cells
(MCs) are localized in association with the peripheral nervous system (PNS) and the brain …

Background Pain is generally concomitant with an inflammatory reaction at the site where
the nociceptive fibers are activated. Rodent studies suggest that a sterile meningeal …

Recently discovered mechanosensitive Piezo channels emerged as the main molecular
detectors of mechanical forces. The functions of Piezo channels range from detection of …

Nociceptor sensory neurons innervate barrier tissues that are constantly exposed to
microbial stimuli. During infection, pathogenic microorganisms can breach barrier surfaces …

Mast cells are tissue-resident immune cells that play key roles in the initiation and
perpetuation of allergic inflammation, usually through IgE-mediated mechanisms. Mast cells …

Migraines constitute a common neurological and headache disorder affecting around 15%
of the world's population. In addition to other mechanisms, neurogenic neuroinflammation …

The mast cells (MCs) are the leader cells of inflammation. They are well known for their
involvement on allergic reactions through degranulation and release of vasoactive …

Mast cells are the major effectors in allergic reactions through degranulation and release of
inflammatory, vasoactive and nociceptive mediators associated with the pathogenesis of a …

5‐hydroxytryptamine (5‐HT; serotonin) is traditionally considered as a key mediator
implicated in migraine. Multiple 5‐HT receptor subtypes contribute to a variety of region …

Background Engaging the endocannabinoid system through inhibition of monoacylglycerol
lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids …