Deamidated, isomerized, and racemized aspartyl and asparaginyl residues represent a
significant part of the spontaneous damage to proteins that results from the aging process …

The dipeptide carnosine has been observed to exert antiaging activity at cellular and whole
animal levels. This review discusses the possible mechanisms by which carnosine may …

Formation of β-linked Asp-Xaa peptide bonds–isoaspartyl (isoAsp) sites–arise in proteins
via succinimide− linked deamidation of asparagine or dehydration of aspartate, reactions …

Background The development of lethal cancer metastasis depends on the dynamic
interactions between cancer cells and the tumor microenvironment, both of which are …

The formation of abnormal amino acid residues is a major source of spontaneous age-
related protein damage in cells. The protein l-isoaspartyl methyltransferase (PIMT) combats …

Significance: Various autoimmune syndromes are characterized by abnormalities found at
the level of tissues and cells, as well as by microenvironmental influences, such as reactive …

Protein methylation plays important roles in most, if not all, cellular processes. Lysine and
arginine methyltransferases are known to regulate the function of histones and non-histone …

MicroRNAs are small 19–25 nucleotides which have been shown to play important roles in
the regulation of gene expression in many organisms. Downregulation or accumulation of …

Abstract Background Protein L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1) is a
highly conserved protein repair enzyme that participates in regulating the progression of …

Abstract Mammalian sterile 20-like kinase 1 (MST1) is found to promote neuronal apoptosis.
Protein-l-isoaspartate (d-aspartate) O-methyltransferase (PCMT1), an anti-apoptosis factor …