The concern impeding the success of chemotherapy in leukemia treatment is descending
efficacy of drugs because of multiple drug resistance (MDR). The previous failure of …

The identification of tumor cell-specific surface markers is a key step towards personalized
cancer medicine, allowing early assessment and accurate diagnosis, and development of …

Covalent aptamers are novel biochemical tools for fast and selective transfer of labels to
target proteins. Equipped with cleavable electrophiles, these nucleic acid probes enable the …

The development of an aptamer-based therapeutic has rapidly progressed following the first
two reports in the 1990s, underscoring the advantages of aptamer drugs associated with …

Surface modification could enhance the cell internalization efficiency of nanovehicles for
targeted gene or drug delivery. However, the influence of surface modification parameters …

Despite improvements in B cell acute lymphoblastic leukemia (B-ALL) treatment, a
significant number of patients experience relapse of the disease, resulting in poor prognosis …

A novel heterogeneous architecture has been constructed integrating two-dimensional (2D)
bimetallic CoCu–zeolite imidazole framework (CoCu-ZIF) and zero-dimensional (0D) Ti 3 C …

Melanoma is one of the most aggressive and deadly skin cancers, and although
histopathological criteria are used for its prognosis, biomarkers are necessary to identify the …

Plasma membrane proteins are a special class of biomolecules present on the cellular
membrane. They provide the transport of ions, small molecules, and water in response to …

The escape from immune surveillance is a hallmark of cancer progression. The classic
immune checkpoint molecules PD-1, PD-L1, CTLA-4, LAG-3, TIM-3 novel ones are part of a …