Lipid Nanoparticle Delivery of Small Proteins for Potent In Vivo RAS Inhibition
Mutated RAS proteins are potent oncogenic drivers and have long been considered
“undruggable”. While RAS-targeting therapies have recently shown promise, there remains …
“undruggable”. While RAS-targeting therapies have recently shown promise, there remains …
LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer
R Rudalska, J Harbig, MT Snaebjornsson, S Klotz… - Nature Cancer, 2021 - nature.com
The success of molecular therapies targeting specific metabolic pathways in cancer is often
limited by the plasticity and adaptability of metabolic networks. Here we show that …
limited by the plasticity and adaptability of metabolic networks. Here we show that …
An extended transcription factor regulatory network controls hepatocyte identity
Cell identity is specified by a core transcriptional regulatory circuitry (CoRC), typically limited
to a small set of interconnected cell‐specific transcription factors (TFs). By mining global …
to a small set of interconnected cell‐specific transcription factors (TFs). By mining global …
Pivotal role of intestinal cholesterol and nuclear receptor LXR in metabolic liver steatohepatitis and hepatocarcinoma
E Piccinin, M Arconzo, E Pasculli, AF Tricase… - Cell & Bioscience, 2024 - Springer
Hepatocellular carcinoma (HCC) incidence is continuously increasing worldwide, due to the
rise of metabolic dysfunction-associated steatohepatitis (MASH) cases. Cholesterol is an …
rise of metabolic dysfunction-associated steatohepatitis (MASH) cases. Cholesterol is an …
[PDF][PDF] Emerging and potential use of CRISPR in human liver
CRISPR is a gene editing tool adapted from naturally occurring defense systems from
bacteria. It is a technology that is revolutionizing the interrogation of gene functions in driving …
bacteria. It is a technology that is revolutionizing the interrogation of gene functions in driving …
[PDF][PDF] An extended transcription factor regulatory network involving stabilization loops controls hepatocyte identity
Cell identity is specified by a core transcriptional regulatory circuitry (CoRC), typically limited
to a small set of interconnected cell-specific transcription factors (TFs). By mining global …
to a small set of interconnected cell-specific transcription factors (TFs). By mining global …