Toll‐like receptors (TLRs): An old family of immune receptors with a new face in cancer pathogenesis

Y Mokhtari, A Pourbagheri‐Sigaroodi… - Journal of Cellular …, 2021 - Wiley Online Library
In the dark path of tumorigenesis, the more carefully the cancer biology is studied, the more
brilliant answers could be given to the countless questions about its orchestrating derivers …

Toll‐like receptors: The role in bladder cancer development, progression and immunotherapy

S Ohadian Moghadam… - Scandinavian journal of …, 2019 - Wiley Online Library
Bladder cancer is one of the leading causes of death worldwide. The main immune
mechanisms which lead to bladder cancer development or treatment outcomes have yet to …

Macrophages directly kill bladder cancer cells through TNF signaling as an early response to BCG therapy

MF Martínez-López, CR de Almeida… - Disease Models & …, 2024 - journals.biologists.com
ABSTRACT The Bacillus Calmette–Guérin (BCG) vaccine is the oldest cancer
immunotherapeutic agent in use. Despite its effectiveness, its initial mechanisms of action …

Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking

Y Lv, Z Liu, L Deng, S Xia, Q Mu, B Xiao, Y Xiu… - Scientific Reports, 2024 - nature.com
Patients with bladder cancer (BLCA) still show high recurrence after surgery and
chemotherapy. Hesperetin (HE), as a natural compound, has attracted researchers' attention …

Current status and future perspectives of immunotherapy in bladder cancer treatment

Z Wu, J Liu, R Dai, S Wu - Science China Life Sciences, 2021 - Springer
The treatment strategy of bladder cancer has evolved not only through the traditional
modalities of surgery and chemotherapy but also by immunotherapy over the past several …

The mechanisms, functions and clinical applications of miR-542-3p in human cancers

SH Alshahrani, N Rakhimov, J Gupta… - … -Research and Practice, 2023 - Elsevier
MicroRNAs, as a major type of noncoding RNAs, have crucial roles in various functions
during development. Available data have shown that miR-542-3p decreased in various …

CircRNA_0058063 functions as a ceRNA in bladder cancer progression via targeting miR-486-3p/FOXP4 axis

H Liang, H Huang, Y Li, Y Lu, T Ye - Bioscience Reports, 2020 - portlandpress.com
Emerging evidence has uncovered critical regulatory roles of circular RNAs (circRNAs)
function as dynamic scaffolding molecules in tumorigenesis and progression. However, the …

Identification and validation of novel biomarkers affecting bladder cancer immunotherapy via machine learning and its association with M2 macrophages

J Wang, X He, Y Bai, G Du, M Cai - Frontiers in Immunology, 2022 - frontiersin.org
Background Immunotherapy has shown promising results in bladder cancer therapy options.
Methods Analysis of open-access data was conducted using the R software. Open-access …

OncoTherad® (MRB-CFI-1) Nanoimmunotherapy: A Promising Strategy to Treat Bacillus Calmette–Guérin-Unresponsive Non-Muscle-Invasive Bladder Cancer …

JCC Alonso, BR de Souza, IB Reis… - International Journal of …, 2023 - mdpi.com
This study assessed the safety and efficacy of OncoTherad®(MRB-CFI-1)
nanoimmunotherapy for non-muscle invasive bladder cancer (NMIBC) patients …

Immunological mechanisms of intravesical chitosan/interleukin-12 immunotherapy against murine bladder cancer

SG Smith, JL Baltz, BP Koppolu… - …, 2017 - Taylor & Francis
There is a critical unmet clinical need for bladder cancer immunotherapies capable of
inducing durable antitumor immunity. We have shown that four intravesical treatments with a …