The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …

Superoxide, O2•−, is formed in all living organisms that come in contact with air, and,
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …

Reactive Oxygen Species (ROS) are produced during normal cellular function. ROS include
hydroxyl radicals, superoxide anion, hydrogen peroxide and nitric oxide. They are very …

Superoxide dismutases (SODs) are necessary antioxidant enzymes that protect cells from
reactive oxygen species (ROS). Decreased levels of SODs or mutations that affect their …

Superoxide dismutases are enzymes that function to catalytically convert superoxide radical
to oxygen and hydrogen peroxide. These enzymes carry out catalysis at near diffusion …

The discovery of superoxide dismutases (SODs), which convert superoxide radicals to
molecular oxygen and hydrogen peroxide, has been termed the most important discovery of …

[Frontiers in Bioscience 4, d339-345, March 15, 1999] ANTIOXIDANT ENZYMES AND THEIR
IMPLICATIONS IN PATHOPHYSIOLOGIC PROCESSES J Page 1 [Frontiers in Bioscience 4 …

Mitochondria constitute a primary locus for the intracellular formation and reactions of
peroxynitrite, and these interactions are recognized to contribute to the biological and …

The 1.30 Å resolution crystal structure of nickel superoxide dismutase (NiSOD) identifies a
novel SOD fold, assembly, and Ni active site. NiSOD is a hexameric assembly of right …

In biological systems there is a balance between the production and neutralization of
reactive oxygen species (ROS). This balance is maintained by the presence of natural …