The unusual regenerative properties of the liver are a logical adaptation by organisms, as
the liver is the main detoxifying organ of the body and is likely to be injured by ingested …

The liver possesses the unique ability to regenerate within a short period of time, a feature
that has led to the development of innovative strategies in liver surgery and transplantation …

Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide and
available therapies, including immunotherapies, are ineffective for many patients. HCC is …

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is
activated by many cytokines and growth factors and plays a key role in cell survival …

The Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling
pathway, activated by more than 50 cytokines or growth factors, plays critical roles in a wide …

Increasing evidence demonstrates that IL-6 has a protective role during liver injury. IL-6
activates intracellular pathways via the gp130 receptor. In order to identify IL-6–gp130 …

Summary Cardiotrophin-1 (CT-1) is a member of the gp130 family of cytokines. We observed
that ct-1−/− mice develop mature-onset obesity, insulin resistance, and …

ETHNOPHARMACOLOGICAL RELEVANCE: Steroidal saponins from Dioscorea
zingiberensis are widely used in China for curing cardiovascular diseases. However, there …

Clinically, the Fas and Fas ligand system plays a central role in the development of
hepatocyte apoptosis, a process contributing to a broad spectrum of liver diseases …

Acute liver failure is marked by the rapid deterioration of liver function in a previously well
patient over period of days to weeks. Though relatively rare, it is associated with high …