In type 2 diabetes mellitus (T2DM) and its related disorders like obesity, the abnormal
protein processing, oxidative stress and proinflammatory cytokines will drive the activation of …

Melatonin, a pineal gland synthesized neurohormone is known as a multifunctioning
pleiotropic agent which has a wide range of neuroprotective role in manifold age-related …

While melatonin is known to have protective effects in mitochondria‐related diseases, aging,
and neurodegenerative disorders, there is poor understanding of the effects of melatonin …

Coffee is the most widely used beverage globally and contains many bioactive compounds,
including phenolic compounds, alkaloids, triterpenes, organic acids, amino acids …

Coronaviruses (CoVs) are a group of single stranded RNA viruses, of which some of them
such as SARS-CoV, MERS-CoV, and SARS-CoV-2 are associated with deadly worldwide …

Rupture of vulnerable plaques is the main trigger of acute cardio‐cerebral vascular events,
but mechanisms responsible for transforming a stable atherosclerotic into a vulnerable …

Melatonin and novel melatonin-based therapies such as melatonin-containing hybrid
molecules, melatonin analogues, and melatonin derivatives have been investigated as …

Clinical sequelae and symptoms for a considerable number of COVID-19 patients can linger
for months beyond the acute stage of SARS-CoV-2 infection,“long COVID”. Among the long …

Iron overload as a highly risk factor, can be found in almost all human chronic and common
diseases. Iron chelators are often used to treat iron overload; however, patient adherence to …

Brain insulin resistance, induced by neuroinflammation and oxidative stress, contributes to
neurodegeneration, that is, processes that are associated with Aβ accumulation and TAU …