Use of zebrafish in drug discovery toxicology

S Cassar, I Adatto, JL Freeman, JT Gamse… - Chemical research in …, 2019 - ACS Publications
Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

A review of the direct and indirect effects of neonicotinoids and fipronil on vertebrate wildlife

D Gibbons, C Morrissey, P Mineau - Environmental Science and Pollution …, 2015 - Springer
Concerns over the role of pesticides affecting vertebrate wildlife populations have recently
focussed on systemic products which exert broad-spectrum toxicity. Given that the …

Skeletal anomalies in reared E uropean fish larvae and juveniles. Part 2: main typologies, occurrences and causative factors

C Boglione, E Gisbert, P Gavaia… - Reviews in …, 2013 - Wiley Online Library
The presence of skeletal anomalies in farmed teleost fish is currently a major problem in
aquaculture, entailing economical, biological and ethical issues. The common occurrence of …

Role of environmental contaminants in the etiology of Alzheimer's disease: a review

M Yegambaram, B Manivannan… - Current Alzheimer …, 2015 - ingentaconnect.com
Alzheimer's dis ease (AD) is a leading cause of mortality in the developed world with 70%
risk attributable to genetics. The remaining 30% of AD risk is hypothesized to include …

Multidimensional In Vivo Hazard Assessment Using Zebrafish

L Truong, DM Reif, L St Mary, MC Geier… - Toxicological …, 2014 - academic.oup.com
There are tens of thousands of man-made chemicals in the environment; the inherent safety
of most of these chemicals is not known. Relevant biological platforms and new …

Revisiting pesticide pollution: The case of fluorinated pesticides

DAM Alexandrino, CMR Almeida, AP Mucha… - Environmental …, 2022 - Elsevier
Fluorinated pesticides acquired a significant market share in the agrochemical sector due to
the surge of new fluoroorganic ingredients approved in the last two decades. This growing …

[图书][B] The toxicology of fishes

RT Di Giulio, DE Hinton - 2008 - taylorfrancis.com
When looking for a book on fish toxicology, you might find one that discusses the
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …

Fipronil insecticide toxicology: oxidative stress and metabolism

X Wang, MA Martínez, Q Wu, I Ares… - Critical reviews in …, 2016 - Taylor & Francis
Fipronil (FIP) is widely used across the world as a broad-spectrum phenylpyrazole
insecticide and veterinary drug. FIP was the insecticide to act by targeting the γ-aminobutyric …

Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS

X Shi, Y Du, PKS Lam, RSS Wu, B Zhou - Toxicology and applied …, 2008 - Elsevier
Perfluorooctanesulfonate (PFOS) is a persistent organic pollutant, the potential toxicity of
which is causing great concern. In the present study, we employed zebrafish embryos to …

[HTML][HTML] Size-dependent seizurogenic effect of polystyrene microplastics in zebrafish embryos

S Jeong, S Jang, SS Kim, MA Bae, J Shin… - Journal of Hazardous …, 2022 - Elsevier
The effects of polystyrene microplastic (PS-MP) size on neurotoxicity remain to be evaluated
at various microsizes, and the seizurogenic effects of PS-MPs are unknown. This study …