Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets
Alzheimer's disease (AD), the most common form of dementia, is recognized as a
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
[HTML][HTML] Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …
[HTML][HTML] Transcriptomic and epigenomic landscapes of Alzheimer's disease evidence mitochondrial-related pathways
A Marmolejo-Garza, T Medeiros-Furquim, R Rao… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Alzheimer's Disease (AD) is the main cause of dementia and it is defined by cognitive
decline coupled to extracellular deposit of amyloid-beta protein and intracellular …
decline coupled to extracellular deposit of amyloid-beta protein and intracellular …
Analysis framework and experimental design for evaluating synergy-driving gene expression
The mechanisms by which genetic risk variants interact with each other, as well as
environmental factors, to contribute to complex genetic disorders remain unclear. We …
environmental factors, to contribute to complex genetic disorders remain unclear. We …
[HTML][HTML] Systematic Analysis of Biological Processes Reveals Gene Co-expression Modules Driving Pathway Dysregulation in Alzheimer's Disease
Alzheimer's disease (AD) manifests as a complex systems pathology with intricate interplay
among various genes and biological processes. Traditional differential gene expression …
among various genes and biological processes. Traditional differential gene expression …
Genome-wide prediction and integrative functional characterization of Alzheimer's disease-associated genes
The mechanism of Alzheimer's disease (AD) remains elusive, partly due to the incomplete
identification of risk genes. We developed an approach to predict AD-associated genes by …
identification of risk genes. We developed an approach to predict AD-associated genes by …