Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …

Pulmonary hypertension (PH) is characterized by pulmonary artery remodeling that can
subsequently culminate in right heart failure and premature death. Emerging evidence …

Cancer cells are metabolically vigorous and are superior in the uptake of nutrients and in the
release of the tumor microenvironment (TME)-specific metabolites. They create an acidic …

Most eukaryotes require oxygen for their survival and, with increasing multicellular
complexity, oxygen availability and delivery rates vary across the tissues of complex …

Abstract Interleukin 9 (IL-9)-producing helper T (Th9) cells are essential for inducing anti-
tumor immunity and inflammation in allergic and autoimmune diseases. Although …

The prolyl hydroxylase domain-containing (PHD or EGL9-homologs) enzyme family is
mainly known for its role in the cellular response to hypoxia. HIF-PH inhibitors can stabilize …

The hypoxia‐inducible factor 1α (HIF‐1α) is critically involved in tissue regeneration. Hence,
the pharmacological prevention of HIF‐1α degradation by prolyl hydroxylase (PHD) under …

Inflammatory bowel disease (IBD) is a chronic disease that is characterized by intestinal
inflammation. Epithelial damage and loss of intestinal barrier function are believed to be the …

Alterations in microRNA (miRNA) profiles, induced by tumor microenvironment stressors,
like hypoxia, allow cancer cells to acquire immune-resistance phenotypes. Indeed, hypoxia …

Malignant ascites is one of the major clinical features of ovarian cancer, which serves as a
carrier for the peritoneal dissemination of tumor cells and predicts a poor prognosis in …