Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry
owing to its synthetic merits and the ubiquitous presence of amines among biologically …

1.1. Brief Historical Overview As expected from the fluorine position on the periodic table of
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

The five selective serotonin reuptake inhibitors (SSRIs), fluoxetine, fluvoxamine, paroxetine,
sertraline, and citalopram, have similar antidepressant efficacy and a similar side effect …

A highly para-selective aromatic C–H borylation has been accomplished. By a new iridium
catalyst bearing a bulky diphosphine ligand, Xyl-MeO-BIPHEP, the C–H borylation of …

Background: Single isomers of the selective serotonin reuptake inhibitors citalopram
(escitalopram, S-citalopram) and fluoxetine (R-fluoxetine) are currently under development …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

The present survey compares the effects of antidepressants and their principal metabolites
on reuptake of biogenic amines and on receptor binding. The following antidepressants …

This paper presents an overview of the clinically relevant pharmacology of selective
serotonin reuptake inhibitors (SSRIs) with an emphasis on their pharmacokinetics and …

Objective: This review aimed to provide distinct dose recommendations for antidepressants
based on the genotypes of cytochrome P450 enzymes CYP2D6 and CYP2C19. This …