Histone acetylation: molecular mnemonics on the chromatin
Long-lasting memories require specific gene expression programmes that are, in part,
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …
[HTML][HTML] Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders
N Singewald, C Schmuckermair, N Whittle… - Pharmacology & …, 2015 - Elsevier
Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …
Tet1 is critical for neuronal activity-regulated gene expression and memory extinction
The ten-eleven translocation (Tet) family of methylcytosine dioxygenases catalyze oxidation
of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and promote DNA …
of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and promote DNA …
HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner
M Malvaez, SC McQuown, GA Rogge… - Proceedings of the …, 2013 - National Acad Sciences
Nonspecific histone deacetylase (HDAC) inhibition has been shown to facilitate the
extinction of drug-seeking behavior in a manner resistant to reinstatement. A key open …
extinction of drug-seeking behavior in a manner resistant to reinstatement. A key open …
The role of histone acetylation in memory formation and cognitive impairments
Long-term memory formation requires transcription and protein synthesis. Over the past few
decades, a great amount of knowledge has been gained regarding the molecular players …
decades, a great amount of knowledge has been gained regarding the molecular players …
The potential of HDAC inhibitors as cognitive enhancers
Histone acetylation is a prominent epigenetic modification of the central nervous system that
is unequivocally associated with an increase in the rate of gene transcription. Because gene …
is unequivocally associated with an increase in the rate of gene transcription. Because gene …
Histone deacetylases in memory and cognition
Over the past 30 years, lysine acetylation of histone and nonhistone proteins has become
established as a key modulator of gene expression regulating numerous aspects of cell …
established as a key modulator of gene expression regulating numerous aspects of cell …
Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation
5-hydroxymethylcytosine (5-hmC) is a novel DNA modification that is highly enriched in the
adult brain and dynamically regulated by neural activity. 5-hmC accumulates across the …
adult brain and dynamically regulated by neural activity. 5-hmC accumulates across the …
Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders
Ageing is the main risk factor for human neurological disorders. Among the diverse
molecular pathways that govern ageing, epigenetics can guide age-associated decline in …
molecular pathways that govern ageing, epigenetics can guide age-associated decline in …
[HTML][HTML] Histone deacetylases (HDACs) and brain function
CH Volmar, C Wahlestedt - Neuroepigenetics, 2015 - Elsevier
Modulation of gene expression is a constant and necessary event for mammalian brain
function. An important way of regulating gene expression is through the remodeling of …
function. An important way of regulating gene expression is through the remodeling of …