Combination therapy for multi-target manipulation of secondary brain injury mechanisms

MR Somayaji, AJ Przekwas… - Current …, 2018 - ingentaconnect.com
Traumatic brain injury (TBI) is a major healthcare problem that affects millions of people
worldwide. Despite advances in understanding and developing preventative and treatment …

Integrating human and nonhuman primate data to estimate human tolerances for traumatic brain injury

T Wu, F Sato, J Antona-Makoshi… - Journal of …, 2022 - asmedigitalcollection.asme.org
Traumatic brain injury (TBI) contributes to a significant portion of the injuries resulting from
motor vehicle crashes, falls, and sports collisions. The development of advanced …

Investigation of cross-species scaling methods for traumatic brain injury using finite element analysis

T Wu, J Antona-Makoshi, A Alshareef… - Journal of …, 2020 - liebertpub.com
Scaling methods are used to relate animal exposure data to humans by determining
equivalent biomechanical impact conditions that result in similar tissue-level mechanics for …

A review of head injury metrics used in automotive safety and sports protective equipment

B Rowson, SM Duma - Journal of biomechanical …, 2022 - asmedigitalcollection.asme.org
Despite advances in the understanding of human tolerances to brain injury, injury metrics
used in automotive safety and protective equipment standards have changed little since they …

Identification of the visco-hyperelastic properties of brain white matter based on the combination of inverse method and experiment

Q Liu, J Liu, F Guan, X Han, L Cao, K Shan - Medical & biological …, 2019 - Springer
To fully understand the brain injury mechanism and develop effective protective approaches,
an accurate constitutive model of brain tissue is firstly required. Generally, the brain tissue is …

[PDF][PDF] Multiscale modelling of blast-induced TBI mechanobiology-from body to neuron to molecule

RK Gupta, XG Tan, MR Somayaji, AJ Przekwas - Def Life Sci J, 2017 - researchgate.net
Blast induced traumatic brain injury (bTBI) has become a signature wound of the recent
military operations and is becoming a significant factor of recent civilian blast explosion …

Effect of aging on brain injury prediction in rotational head trauma—a parameter study with a rat finite element model

J Antona-Makoshi, E Eliasson, J Davidsson… - Traffic injury …, 2015 - Taylor & Francis
Objective: The aim of this study was to investigate the possible effects of age-related
intracranial changes on the potential outcome of diffuse axonal injuries and acute subdural …

Development of a subhuman primate brain finite element model to investigate brain injury thresholds induced by head rotation

T Arora - 2018 - search.proquest.com
The brain is the most critical organ of the human body as it controls motor function,
information flow and body actions. Thus, the brain needs to be protected from trauma …

Development of a comprehensive injury criterion for moderate and mild traumatic brain injuries

J Antona-Makoshi, J Davidsson, S Ejima… - International journal of …, 2016 - jstage.jst.go.jp
Traumatic brain injuries are commonly caused by blows that produce sudden accelerations
of the head. A methodology to define a new global brain injury criterion and thresholds that …

Computational biomechanics of blast-induced traumatic brain injury: role of loading directionality, head protection, and blast flow mechanics

H Sarvghad-Moghaddam - 2015 - search.proquest.com
In this dissertation, blast-induced traumatic brain injury (bTBI) is studied with respect to the
blast wave directionality, mitigation capability of helmet/faceshield, and blast flow mechanics …