Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …

Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various
aspects of cancer progression. The metabolic reprogramming of amino acids in tumor cells …

There is a need to develop effective therapies for pancreatic ductal adenocarcinoma (PDA),
a highly lethal malignancy with increasing incidence and poor prognosis. Although targeting …

Tumor-associated macrophages (TAMs) are a heterogeneous population of cells whose
phenotypes and functions are shaped by factors that are incompletely understood. Herein …

Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive
metabolic programs for survival and proliferation. Therefore, knowledge of …

Pancreatic cancer is an aggressive cancer with a poor prognosis. Metabolic abnormalities
are one of the hallmarks of pancreatic cancer, and pancreatic cancer cells can adapt to …

Uterine fibroids (UF), also called uterine leiomyoma, is one of the most prevalent uterine
tumors. UF represents a serious women's health global problem with a significant physical …

The tumor microenvironment (TME), which is mostly composed of tumor cells, immune cells,
signaling molecules, stromal tissue, and the vascular system, is an integrated system that is …

During development of pancreatic cancer macrophage-mediated inflammatory processes
and the formation of cancerous lesions are tightly connected. Based on insight from mouse …

Tumorigenesis embodies the formation of a heterotypic tumour microenvironment (TME)
that, among its many functions, enables the evasion of T cell-mediated immune responses …