This article reviews the discovery of PCSK9, its structure–function characteristics, and its
presently known and proposed novel biological functions. The major critical function of …

Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

The modification of eukaryotic proteins by isoprenoid lipids, which is known as prenylation,
controls the localization and activity of a range of proteins that have crucial functions in …

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions,
ranging from cholesterol synthesis to growth control. Several mechanisms for feedback …

Although the roots of Ras sprouted from the rich history of retrovirus research, it was the
discovery of mutationally activated RAS genes in human cancer in 1982 that stimulated an …

From the pioneering work with acute transforming retroviruses to the current post-genomic
era, RAS genes have always been at the leading edge of signal transduction and molecular …

Extensive research on the Ras proteins and their functions in cell physiology over the past
30 years has led to numerous insights that have revealed the involvement of Ras not only in …

Extensive epidemiologic studies performed in many countries have shown that increased
blood cholesterol levels, or, more specifically, increased levels of LDL-cholesterol, are …

Ras proteins participate as a molecular switch in the early steps of the signal transduction
pathway that is associated with cell growth and differentiation. When the protein is in its GTP …