Cells continually experience stress and damage from exogenous and endogenous sources,
and their responses range from complete recovery to cell death. Proliferating cells can …

Many different chromosomal races with reduced chromosome number due to the presence
of Robertsonian fusion metacentrics have been described in western Europe and northern …

Histone modifications might act to mark and maintain functional chromatin domains during
both interphase and mitosis. Here we show that pericentric heterochromatin in mammalian …

Background Similarities as well as differences in higher order chromatin arrangements of
human cell types were previously reported. For an evolutionary comparison, we now studied …

Abstract Heterochromatin protein 1 (HP1) is a nonhistone chromosomal protein, first
identified in Drosophila, that plays a dose-dependent role in gene silencing. Three …

Background The observation of multiple genetic markers in situ by optical microscopy and
their relevance to the study of three-dimensional (3D) chromosomal organization in the …

Upon fertilization, reprogramming of gene expression is required for embryo development.
This step is marked by DNA demethylation and changes in histone variant composition …

Although a growing number of studies investigates functional genome organization in
somatic cell nuclei, it is largely unknown how mammalian genome organization is …

In mammals, Robertsonian (Rb) translocation (the joining of two telo/acrocentric
chromosomes at their centromere to form a metacentric) is the most effective process in …

Constitutive heterochromatin mainly consists of different classes of satellite DNAs and is
defined as a transcriptionally inactive chromatin that remains compact throughout the cell …