Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …

Psoriasis is a complex chronic inflammatory skin disease caused by the dynamic interplay
between multiple genetic risk foci, environmental risk factors, and excessive immunological …

Background Although atopic dermatitis (AD) often presents in infancy and persists into
adulthood, comparative characterization of AD skin among different pediatric age groups is …

The role of the microbiota in the development and function of γδ T cells—a T cell subset
characterized by a T cell receptor composed of one γ-chain and one δ-chain—has been …

The skin is an organ harboring several types of immune cells that participate in innate and
adaptive immune responses. The immune system of the skin comprises both skin cells and …

Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and
recently, all of its related receptors have been discovered. IL-17 was first discovered …

Objective Adoptive Treg cell therapy has great potential to treat autoimmune disease.
Currently, very little is known about how these cells impact inflamed tissues. This study was …

Abstract IL-17A-producing CD4+ T helper cells (Th17) are crucial for the development of
inflammatory and autoimmune diseases and thus are exploited for clinical immunotherapies …

IL-17 was discovered nearly 30 yr ago, but it has only been recently appreciated that a key
function of this cytokine is to orchestrate cellular and organismal metabolism. Indeed …

Background Biomarkers of atopic dermatitis (AD) are largely lacking, especially in infant AD.
Those that have been examined to date have focused mostly on serum cytokines, with few …