Role of dietary polyphenols on gut microbiota, their metabolites and health benefits

SM Aravind, S Wichienchot, R Tsao… - Food Research …, 2021 - Elsevier
The beneficial health roles of dietary polyphenols in preventing oxidative stress related
chronic diseases have been subjected to intense investigation over the last two decades. As …

Diet, microorganisms and their metabolites, and colon cancer

SJD O'keefe - Nature reviews Gastroenterology & hepatology, 2016 - nature.com
Colorectal cancer is one of the so-called westernized diseases and the second leading
cause of cancer death worldwide. On the basis of global epidemiological and scientific …

Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health …

FA Tomás‐Barberán… - Molecular nutrition & …, 2017 - Wiley Online Library
Urolithins are dibenzo [b, d] pyran‐6‐one derivatives that are produced by the human gut
microbiota from ellagitannins and ellagic acid (EA). These metabolites are much better …

Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update

A Rodriguez-Mateos, D Vauzour, CG Krueger… - Archives of …, 2014 - Springer
There is substantial interest in the role of plant secondary metabolites as protective dietary
agents. In particular, the involvement of flavonoids and related compounds has become a …

Increased systolic and diastolic blood pressure is associated with altered gut microbiota composition and butyrate production in early pregnancy

LF Gomez-Arango, HL Barrett, HD McIntyre… - …, 2016 - Am Heart Assoc
The risk of developing pregnancy-induced hypertension and preeclampsia is higher in
obese pregnant women. In obesity, the composition of the gut microbiota is altered. Obesity …

Ellagic acid and intestinal microflora metabolite urolithin A: A review on its sources, metabolic distribution, health benefits, and biotransformation

M Zhang, S Cui, B Mao, Q Zhang, J Zhao… - Critical reviews in …, 2023 - Taylor & Francis
Foods rich in ellagic tannins are first hydrolyzed into ellagic acid in the stomach and small
intestine, and then converted into urolithins with high bioavailability by the intestinal flora …

Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

V Baradaran Rahimi, M Ghadiri… - Phytotherapy …, 2020 - Wiley Online Library
Inflammation is commonly characterized as a defensive and protective reaction of the body
to various exogenous or endogenous stimuli, which aims to maintain the body health …

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice

Z Gong, J Huang, B Xu, Z Ou, L Zhang, X Lin… - Journal of …, 2019 - Springer
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder
characterized by an abnormal accumulation of amyloid-β (Aβ) plaques, neuroinflammation …

Natural polyphenols: a potential prevention and treatment strategy for metabolic syndrome

S Wang, Q Du, X Meng, Y Zhang - Food & Function, 2022 - pubs.rsc.org
Metabolic syndrome (MS) is the term for a combination of hypertension, dyslipidemia, insulin
resistance, and central obesity as factors leading to cardiovascular and metabolic disease …

Ellagic acid: Pharmacological activities and molecular mechanisms involved in liver protection

WR García-Niño, C Zazueta - Pharmacological Research, 2015 - Elsevier
Traditional drugs or therapies rarely have effects on regression of chronic liver diseases,
which result in many cases from sustained oxidative stress. In recent years, ellagic acid (EA) …