Tissue-resident immune cells span both myeloid and lymphoid cell lineages, have been
found in multiple human tissues, and play integral roles at all stages of the immune …

Antigen-presenting cells (APCs) are master regulators of the immune response by directly
interacting with T cells to orchestrate distinct functional outcomes. Several types of …

Immunotherapies targeting conventional T cells have revolutionized systemic treatment for
many cancers, yet only a subset of patients benefit from these approaches. A better …

Although the function of the circulating immune cell compartment has been studied in detail
for decades, limitations in terms of access and cell yields from peripheral tissues have …

Type 2 immunity helps protect the host from infection, but it also plays key roles in tissue
homeostasis, metabolism, and repair. Unfortunately, inappropriate type 2 immune reactions …

Tissue-resident immune cells reside in distinct niches across organs, where they contribute
to tissue homeostasis and rapidly respond to perturbations in the local microenvironment …

Whereas the critical roles of innate lymphoid cells (ILCs) in adult are increasingly
appreciated, their developmental hierarchy in early human fetus remains largely elusive. In …

Innate lymphoid cells (ILCs) are highly plastic and predominantly mucosal tissue-resident
cells that contribute to both homeostasis and inflammation depending on the …

Innate lymphoid cells (ILCs) are considered innate counterparts of adaptive T cells;
however, their common and unique transcriptional signatures in pediatric inflammatory …

Although group 3 innate lymphoid cells (ILC3s) are efficient inducers of T cell responses in
the spleen, they fail to induce CD4+ T cell proliferation in the gut. The signals regulating …