A number of proteins are activated by stress stimuli but none so spectacularly or with the
degree of complexity as the tumour suppressor p53 (human p53 gene or protein). Once …

Preterm prelabor rupture of the membranes (pPROM) may lead to preterm births (PTBs). We
investigated premature senescence of fetal membranes in women with pPROM and …

Objective Oxidative stress is a postulated etiology of spontaneous preterm birth (PTB) and
preterm prelabor rupture of the membranes (pPROM); however, the precise mechanistic role …

The most import biological function of the tumor suppressor p53 is that of a sequence-
specific transactivator. In response to a variety of cellular stress stimuli, p53 induces the …

Werner syndrome (WS) patients exhibit premature aging predominantly in mesenchyme-
derived tissues, but not in neural lineages, a consequence of telomere dysfunction and …

Hypoxic stress is one of the major selective pressures in the microenvironment of solid
tumors, and overcoming this restriction is essential for tumor progression. One of the key …

Telomeres are tandem repeats of a specific TTAGGG nucleotide sequence at the ends of
chromosomes. Telomere shortening is proposed to act as a biological clock and cancer …

Biochemical mechanisms of the programmed death phenomena are considered at levels of
unicellular organisms, mitochondria, cells, groups of cells, and organs. Some examples of …

Single-stranded DNA has been speculated to be the initial signal in the DNA damage
signaling pathway. We showed that introduction of single-stranded DNA with diverse …

Different methods of telomere length measurement are used to identify patients with
telomeropathies. In our lab, we established four different methods for telomere length …