Simple Summary Tumor heterogeneity promotes the development of drug resistance in
cancer. HDAC inhibitors modulate several processes that contribute to intra-tumoral …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most incident cancer
worldwide. More than half of HNSCC patients experience locoregional or distant relapse to …

Background Epidermal growth factor receptor (EGFR) is both a driver oncogene and a
therapeutic target in advanced head and neck squamous cell carcinoma (HNSCC) …

Head and neck squamous cell carcinoma (HNSCC) is often being diagnosed at an
advanced stage, conferring a poor prognosis. The probability of local tumor control after …

Although substantial progress has been made in biological research and clinical treatment
in recent years, the clinical prognosis of oral squamous cell carcinoma (OSCC) is still not …

Simple Summary Tumors are not composed of a uniform ball of cells, but rather, a complex
set of diverse cells. Unfortunately, most transcriptomic techniques analyze the entire tumor …

Advances in cancer immunotherapy, particularly immune checkpoint inhibitors, have
dramatically improved the prognosis for patients with metastatic melanoma and other …

Drug resistance is the main obstacle to achieving cures with both conventional and targeted
anticancer drugs. The emergence of acquired drug resistance is initially mediated by non …

Simple Summary Mesenchymal conversion occurring in malignant epithelial neoplasms is
undesirable in tumors since it promotes more aggressive tumor behavior. This phenomenon …

We present scTenifoldNet—a machine learning workflow built upon principal-component
regression, low-rank tensor approximation, and manifold alignment—for constructing and …