Recent advances in the direct functionalization of quinoxalin-2 (1 H)-ones

Q Ke, G Yan, J Yu, X Wu - Organic & Biomolecular Chemistry, 2019 - pubs.rsc.org
The direct C3-functionalization of quinoxalin-2 (1H)-ones via C–H bond activation has
recently attracted considerable attention, due to their diverse biological activities and …

Visible-light-induced decarboxylative acylation of quinoxalin-2 (1 H)-ones with α-oxo carboxylic acids under metal-, strong oxidant-and external photocatalyst-free …

LY Xie, YS Bai, XQ Xu, X Peng, HS Tang, Y Huang… - Green …, 2020 - pubs.rsc.org
A mild and eco-friendly visible-light-induced decarboxylative acylation of quinoxalin-2 (1H)-
ones and α-oxo carboxylic acids with ambient air as the sole oxidant at room temperature …

Aryl acyl peroxides for visible-light induced decarboxylative arylation of quinoxalin-2 (1H)-ones under additive-, metal catalyst-, and external photosensitizer-free and …

LY Xie, S Peng, LH Yang, C Peng, YW Lin, X Yu… - Green …, 2021 - pubs.rsc.org
Aryl radicals were generated for the first time from cheap and easily available aryl acyl
peroxides in eco-friendly ethyl acetate under ambient conditions and visible-light …

Photocatalyst-, metal-and additive-free, direct C–H arylation of quinoxalin-2 (1 H)-ones with aryl acyl peroxides induced by visible light

J Xu, H Zhang, J Zhao, Z Ni, P Zhang… - Organic Chemistry …, 2020 - pubs.rsc.org
A visible light-mediated direct C–H arylation of quinoxalin-2 (1H)-ones with aryl acyl
peroxides has been developed. The reaction proceeds smoothly through a radical process …

Recent advances and perspectives on the synthesis and C–H bond functionalization of quinoxalin-2(1H)-one

P Ghosh, S Das - Synthetic Communications, 2020 - Taylor & Francis
Over the past few decades, quinoxalin-2 (1 H)-one derivatives are serving as active
components in diverse families of drugs such as antimicrobial, anticancer, antithrombotic …

Visible Light Photoredox-Catalyzed Direct C–H Arylation of Quinoxalin-2(1H)-ones with Diaryliodonium Salts

RK Samanta, P Meher, S Murarka - The Journal of Organic …, 2022 - ACS Publications
A photoredox-catalyzed direct arylation of quinoxalin-2-(1 H)-ones using diaryliodonium
triflates as the convenient, stable, and cheap aryl source is described. A broad variety of …

Direct para-C–H heteroarylation of anilines with quinoxalinones by metal-free cross-dehydrogenative coupling under an aerobic atmosphere

J Xu, L Huang, L He, C Liang, Y Ouyang, J Shen… - Green …, 2021 - pubs.rsc.org
Herein, a green and efficient metal-free cross-dehydrogenative coupling (CDC) for the direct
para-C–H heteroarylation of anilines with quinoxalinones has been described. This reaction …

Synthesis of (E)-Quinoxalinone Oximes through a Multicomponent Reaction under Mild Conditions

J Xu, H Yang, L He, L Huang, J Shen, W Li… - Organic …, 2020 - ACS Publications
Herein, a novel method for the gram-scale synthesis of (E)-quinoxalinone oximes through a
multicomponent reaction under mild conditions is described. Such a transformation was …

Transition-metal-free direct C-3 alkylation of quinoxalin-2 (1 H)-ones with ethers

J Yuan, J Fu, J Yin, Z Dong, Y Xiao, P Mao… - Organic Chemistry …, 2018 - pubs.rsc.org
A convenient and efficient transition-metal-free protocol for the synthesis of 3-alkyl
quinoxalin-2 (1H)-ones from the radical reaction of quinoxalin-2 (1H)-ones with ethers was …

Metal-free C3-alkoxycarbonylation of quinoxalin-2(1H)-ones with carbazates as ecofriendly ester sources

LY Xie, S Peng, TG Fan, YF Liu, M Sun, LL Jiang… - Science China …, 2019 - Springer
Quinoxaline-3-carboxylates and analogues are prevalent key structural motifs in bioactive
natural products and synthetic drugs. However, the practical protocol for preparation of these …