A comprehensive account on recent progress in pharmacological activities of benzimidazole derivatives
Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest
among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole …
among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole …
Insights into the current status of privileged N-heterocycles as antileishmanial agents
Leishmania, one of the most important neglected tropical diseases, is endemic in several
regions of the world and hence regarded as a serious threat to public health. Major …
regions of the world and hence regarded as a serious threat to public health. Major …
A facile approach synthesis of benzoylaryl benzimidazole as potential α-amylase and α-glucosidase inhibitor with antioxidant activity
LM Aroua, HR Almuhaylan, FM Alminderej… - Bioorganic …, 2021 - Elsevier
Synthetic routes to a series of benzoylarylbenzimidazol 3a-h have been derived from 3, 4-
diaminobenzophenone and an appropriate arylaldehyde in the presence of ammonium …
diaminobenzophenone and an appropriate arylaldehyde in the presence of ammonium …
Synthesis, molecular docking, and bioactivity study of novel hybrid benzimidazole urea derivatives: a promising α-amylase and α-glucosidase inhibitor candidate with …
LM Aroua, AH Alosaimi, FM Alminderej, S Messaoudi… - Pharmaceutics, 2023 - mdpi.com
A novel series of benzimidazole ureas 3a–h were elaborated using 2-(1 H-benzoimidazol-2-
yl) aniline 1 and the appropriate isocyanates 2a–h. The antioxidant and possible …
yl) aniline 1 and the appropriate isocyanates 2a–h. The antioxidant and possible …
New antileishmanial quinoline linked isatin derivatives targeting DHFR-TS and PTR1: Design, synthesis, and molecular modeling studies
In a search for new drug candidates for one of the neglected tropical diseases,
leishmaniasis, twenty quinoline-isatin hybrids were synthesized and tested for their in vitro …
leishmaniasis, twenty quinoline-isatin hybrids were synthesized and tested for their in vitro …
Homology Modelling and Molecular Docking Studies of Selected Substituted Benzo[d]imidazol-1-yl)methyl)benzimidamide Scaffolds on Plasmodium falciparum …
Plasmodium falciparum adenylosuccinate lyase (Pf ADSL) is an important enzyme in purine
metabolism. Although several benzimidazole derivatives have been commercially …
metabolism. Although several benzimidazole derivatives have been commercially …
Tetrahydrobenzo [h] quinoline derivatives as a novel chemotype for dual antileishmanial-antimalarial activity graced with antitubercular activity: Design, synthesis and …
TM Ibrahim, G Abada, M Dammann, RM Maklad… - European Journal of …, 2023 - Elsevier
Derivatives with tetrahydrobenzo [h] quinoline chemotype were synthesized via one-pot
reactions and evaluated for their antileishmanial, antimalarial and antitubercular activities …
reactions and evaluated for their antileishmanial, antimalarial and antitubercular activities …
Spiro heterocycles bearing piperidine moiety as potential scaffold for antileishmanial activity: synthesis, biological evaluation, and in silico studies
New spiro-piperidine derivatives were synthesised via the eco-friendly ionic liquids in a one-
pot fashion. The in vitro antileishmanial activity against Leishmania major promastigote and …
pot fashion. The in vitro antileishmanial activity against Leishmania major promastigote and …
Theoretical activity prediction, structure-based design, molecular docking and pharmacokinetic studies of some maleimides against Leishmania donovani for the …
Background Leishmaniasis is a neglected tropical disease caused by a group of protozoan
of the genus Leishmani a and transmitted to humans majorly through the bite of the female …
of the genus Leishmani a and transmitted to humans majorly through the bite of the female …
Design, synthesis, molecular docking, ADMET studies, and biological activity evaluation of new 2-({[3-aryl-1, 2, 4-oxadiazol-5-yl) methyl] thio}-1H-benzimidazoles and …
M Sharaf, AH Moustafa, RJ Obaid… - Journal of Molecular …, 2024 - Elsevier
Aryl amidoximes are active binucleophilic compounds used as a powerful and versatile
reagent in synthesizing diverse heterocyclic compounds with pharmacological interest …
reagent in synthesizing diverse heterocyclic compounds with pharmacological interest …