Breast cancer is a multifactorial disease and driven by aberrant regulation of cell signaling
pathways due to the acquisition of genetic and epigenetic changes. An array of growth …

The epithelial mesenchymal transition (EMT) plays a central role in both normal
physiological events (eg, embryonic development) and abnormal pathological events (eg …

Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-
FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective …

Tumor relapse and metastasis are the primary causes of poor survival rates in patients with
advanced cancer despite successful resection or chemotherapeutic treatment. A primary …

Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer. Migration of
circulating tumor cells (CTCs) into the blood stream is an early event that occurs during …

Abstract The CellSearch® system (CS) enables standardized enrichment and enumeration
of circulating tumor cells (CTCs) that are repeatedly assessable via non-invasive “liquid …

In cancer, epithelial-mesenchymal transition (EMT) is associated with metastasis.
Characterizing EMT phenotypes in circulating tumor cells (CTCs) has been challenging …

Dispersion of tumors throughout the body is a neoplastic process responsible for the vast
majority of deaths from cancer. Despite disseminating to distant organs as malignant scouts …

Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors characterized by
aggressive behavior, high risk of distant recurrence, and poor survival. Chemotherapy is still …

Background Breast cancer (BC) is the most common cancer in women, and despite the
introduction of new screening programmes, therapies and monitoring technologies, there is …