Circulation of urate levels is determined by the balance between urate production and
excretion, homeostasis regulated by the function of urate transporters in key epithelial …

Urate is produced in the liver by the degradation of purines from the diet and nucleotide
turnover and excreted by the kidney and gut. The kidney is the major route of urate removal …

SLC2A9 or Glut9 is a voltage sensitive urate transporter, mainly expressed in the kidneys,
the liver, and the intestine. Human Glut9 loss-of-function mutations were identified in familial …

Urate transporters, which are located in the kidneys, significantly affect the level of uric acid
in the body. We looked at genetic variants of genes encoding the major reabsorption …

Verinurad (RDEA3170) is a selective URAT1 inhibitor under investigation for the treatment
of gout and hyperuricemia. In an effort to further improve the pharmacodynamics …

Background Renal hypouricemia (RHUC), a rare inherited disorder characterized by
impaired uric acid (UA) reabsorption in the proximal tubule, is caused by mutations in …

Hyperuricemia is an important risk factor for cardiovascular and renal diseases. Phloretin
had shown antioxidant and anti‐inflammatory properties, but its role in endothelial injury is …

Serum uric acid levels are altered by kidney disorders because the kidneys play a dominant
role in uric acid excretion. Here, major kidney disorders which accompany hyperuricemia or …

Hyperuricemia is a common comorbidity in patients with type 2 diabetes mellitus (T2DM), as
insulin resistance (IR) or hyperinsulinemia is associated with higher serum uric acid (SUA) …

Renal hypouricemia is a disease caused by the dysfunction of renal urate transporters. This
disease is known to cause exercise-induced acute kidney injury, but its mechanism has not …