Oncostatin M (OSM), as a member of the Interleukin-6 family cytokines, plays a significant
role in inflammation, autoimmunity, and cancers. It is mainly secreted by T lymphocytes …

Chronic inflammation has been recognized as a canonical cancer hallmark. It is
orchestrated by cytokines, which are master regulators of the tumor microenvironment (TME) …

The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all
stages of tumor progression. The contribution of stromal cells to the reprogramming of the …

Summary Genomic amplification of 3q26. 2 locus leads to the increased expression of
microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC). Our results …

Abstract Purpose of the Review The bone and hematopoietic tissues coemerge during
development and are functionally intertwined throughout mammalian life. Oncostatin M …

Simple Summary Pro-inflammatory cytokines play a key role in innate-and adaptive-
immunity-mediated liver carcinogenesis. Among these, oncostatin M (OSM) critically …

Background Systemic and chronic inflammatory conditions in patients with breast cancer
have been associated with reduced patient survival and increased breast cancer …

Aberrant angiogenesis is a hallmark of cardiovascular and retinal neovascular disease. The
STAT3 signaling pathway represents a potential pharmacological target for these diseases …

OSMR binding recruits Janus kinases JAK1 and JAK2, leading to the activation of signal
transducers and the activation of transcription factors known as STATs through multiple …

Driven by dysregulated IL-6 family member cytokine signaling in the tumor
microenvironment (TME), aberrant signal transducer and activator of transcription (STAT3) …