Aversive motivation and cognitive control

DM Yee, X Leng, A Shenhav, TS Braver - Neuroscience & Biobehavioral …, 2022 - Elsevier
Aversive motivation plays a prominent role in driving individuals to exert cognitive control.
However, the complexity of behavioral responses attributed to aversive incentives creates …

A role for serotonin in modulating opposing drive and brake circuits of impulsivity

SS Desrochers, MG Spring… - Frontiers in behavioral …, 2022 - frontiersin.org
Impulsivity generally refers to a deficit in inhibition, with a focus on understanding the neural
circuits which constitute the “brake” on actions and gratification. It is likely that increased …

Striatal serotonin release signals reward value

MG Spring, KM Nautiyal - Journal of Neuroscience, 2024 - jneurosci.org
Serotonin modulates diverse phenotypes and functions including depressive, aggressive,
impulsive, and feeding behaviors, all of which have reward-related components. To date …

Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys

Y Hori, K Mimura, Y Nagai, Y Hori, K Kumata… - PLoS …, 2024 - journals.plos.org
Serotonin (5-HT) deficiency is a core biological pathology underlying depression and other
psychiatric disorders whose key symptoms include decreased motivation. However, the …

The contributions of neonatal inhalation of copper to air pollution-induced neurodevelopmental outcomes in mice

J Cubello, E Marvin, K Conrad, AK Merrill, JV George… - Neurotoxicology, 2024 - Elsevier
Exposures to ambient ultrafine particle (UFP) air pollution (AP) during the early postnatal
period in mice (equivalent to human third trimester brain development) produce male-biased …

Fractionating impulsivity and reward-related phenotypes in adolescent mice

R Albert-Lyons, SS Desrochers, C Fengler… - Behavioural Brain …, 2025 - Elsevier
Adolescence is a developmental period characterized by changes in the brain and behavior,
including heightened reward seeking, increased impulsivity, and elevated risk-taking …

Serotonin 1B receptor effects on response inhibition are independent of inhibitory learning

SS Desrochers, KM Nautiyal - Neurobiology of learning and memory, 2022 - Elsevier
Impulsivity is defined in terms of deficits in instrumental response inhibition, when the
inability to withhold an action produces a negative outcome. However, there are many …

The non-hallucinogenic serotonin 1B receptor is necessary for the antidepressant-like effects of psilocybin in mice

S Fleury, KM Nautiyal - BioRxiv, 2024 - biorxiv.org
Recent studies highlight the promising use of psychedelic therapies for psychiatric
disorders, including depression. The persisting clinical effects of psychedelics such as …

Patients with episodic migraine without aura have an increased rate of delayed discounting

L Wang, C Dai, M Gao, Z Geng, P Hu, X Wu… - Brain and …, 2024 - Wiley Online Library
Objective This study aimed to explore decision‐making impulsivity and its neural
mechanisms in patients with episodic migraine without aura (EMoA). Background Previous …

[HTML][HTML] Reward value and internal state differentially drive impulsivity and motivation

R Albert-Lyons, S Capan, KH Ng… - Behavioural Brain …, 2024 - Elsevier
Goal directed behavior is influenced by both reward value as well as internal state and a
large body of research has focused on how reward value and internal drives such as hunger …