In recent years, there has been increasing interest in using biomimetic materials for bone
tissue engineering. However, the high immunogenicity and low mechanical properties of …

Collagen is the main structural protein of most hard and soft tissues in animals and the
human body, which plays an important role in maintaining the biological and structural …

With its wide distribution in soft and hard connective tissues, collagen is the most abundant
of animal proteins. In vitro, natural collagen can be formed into highly organized, three …

The extracellular matrix (ECM) is a complex meshwork of cross-linked proteins providing
both biophysical and biochemical cues that are important regulators of cell proliferation …

Completion of genome sequences for many organisms allows a reasonably complete
definition of the complement of extracellular matrix (ECM) proteins. In mammals this “core …

The interstitium describes the fluid, proteins, solutes, and the extracellular matrix (ECM) that
comprise the cellular microenvironment in tissues. Its alterations are fundamental to …

In the process of matrix assembly, multivalent extracellular matrix (ECM) proteins are
induced to self-associate and to interact with other ECM proteins to form fibrillar networks …

Cells adhere to one another and/or to matrices that surround them. Regulation of cell–cell
(intercellular) and cell–matrix adhesion is tightly controlled in normal cells, however, defects …

Electrospinning is a process that creates nanofibers through an electrically charged jet of
polymer solution or melt. This technique is applicable to virtually every soluble or fusible …

Scientific investigations involving collagen have inspired tissue engineering and design of
biomaterials since collagen fibrils and their networks primarily regulate and define most …