Highlights•Whole-cell modeling could enable rational bioengineering and precision
medicine.•We propose several key principles of whole-cell modeling.•We describe how to …

Many useful applications of simulation in computational cell biology, eg kinetic parameter
estimation, Metabolic Control Analysis (MCA), and bifurcation analysis, require a large …

Stochastic simulation methods have become increasingly widespread as a means of
simulating and analyzing biochemical reaction kinetics. 1 The chemical master equation …

ABSTRACT From the Human Genome Project onwards, biology research has happily
undertaken the path of high-throughput methodologies with the promise that big data would …

As biochemical networks become more popular, the number of simulation tools grows
rapidly. Although most of the tools have similar functionality, they differ in their algorithms …

As biochemical networks become more popular, the number of deterministic simulation tools
grows rapidly. Although most of the tools have similar functionality, they may differ in their …

E-Cell Project [1, 2] at Keio University is aimed at the computer aided reconstruction,
simulation and eventually engineering of the complete spectra of cellular phenomena. As an …

En éste artículo se elabora un estado del arte del problema planteado de simular un modelo
vivo. Se comienza con una estructura elemental como una célula. Claro está que el proceso …

MtDNA mutations in mammalian cells are implicated in cellular ageing and
encephalomyopathies, although mechanisms involved are not completely understood. The …