The liver plays a unique role in controlling carbohydrate metabolism by maintaining glucose
concentrations in a normal range over both short and long periods of times. In type 2 …

The glucokinase (GCK) gene was one of the first candidate genes to be identified as a
human “diabetes gene". Subsequently, important advances were made in understanding the …

Glucokinase, a unique isoform of the hexokinase enzymes, which are known to
phosphorylate d-glucose and other hexoses, was identified during the past three to four …

Conversion of glucose into glycogen is a major pathway that contributes to the removal of
glucose from the portal vein by the liver in the postprandial state. It is regulated in part by the …

This study examines whether anti-diabetic effects of genistein and daidzein are mediated by
hepatic glucose and lipid regulating enzyme activities in type 2 diabetic animals. Male …

The antioxidant activity of lemon balm (Melissa officinalis) essential oil (LBEO) on 2, 2-
diphenyl-1-picrylhydrazyl (DPPH) radicals and its hypoglycaemic effect in db/db mice were …

AMP-activated protein kinase (AMPK) controls glucose uptake and glycolysis in muscle.
Little is known about its role in liver glucose uptake, which is controlled by glucokinase. We …

Type-2 diabetes is associated with impaired glucose clearance by the liver in the
postprandial state, and with elevated glucose production in the post-absorptive state. New …

Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide, affected by
both genetics and environment. Type 2 diabetes (T2D) stands as an independent …

The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose metabolism. We
report here the effects of a novel glucokinase activator, LY2121260. The activator enhanced …