Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer
MC Rangel, D Bertolette, NP Castro… - Breast cancer research …, 2016 - Springer
Cancer has been considered as temporal and spatial aberrations of normal development in
tissues. Similarities between mammary embryonic development and cell transformation …
tissues. Similarities between mammary embryonic development and cell transformation …
Recurrent and pathological gene fusions in breast cancer: current advances in genomic discovery and clinical implications
J Veeraraghavan, J Ma, Y Hu, XS Wang - Breast cancer research and …, 2016 - Springer
Gene fusions have long been considered principally as the oncogenic events of
hematologic malignancies, but have recently gained wide attention in solid tumors due to …
hematologic malignancies, but have recently gained wide attention in solid tumors due to …
Cell landscape of larval and adult Xenopus laevis at single-cell resolution
Y Liao, L Ma, Q Guo, WE, X Fang, L Yang… - nature …, 2022 - nature.com
The rapid development of high-throughput single-cell RNA sequencing technology offers a
good opportunity to dissect cell heterogeneity of animals. A large number of organism-wide …
good opportunity to dissect cell heterogeneity of animals. A large number of organism-wide …
[HTML][HTML] Oncogenic notch promotes long-range regulatory interactions within hyperconnected 3D cliques
Chromatin loops enable transcription-factor-bound distal enhancers to interact with their
target promoters to regulate transcriptional programs. Although developmental transcription …
target promoters to regulate transcriptional programs. Although developmental transcription …
Notch in leukemia
AC McCarter, Q Wang, M Chiang - Molecular mechanisms of notch …, 2018 - Springer
Notch is commonly activated in lymphoid malignancies through ligand-independent and
ligand-dependent mechanisms. In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) …
ligand-dependent mechanisms. In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) …
Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer
M Fournier, J Javary, V Roh, N Fournier… - EMBO Molecular …, 2024 - embopress.org
Cancer cell plasticity contributes significantly to the failure of chemo-and targeted therapies
in triple-negative breast cancer (TNBC). Molecular mechanisms of therapy-induced tumor …
in triple-negative breast cancer (TNBC). Molecular mechanisms of therapy-induced tumor …
Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism
GJ Starrett, AA Serebrenik, PA Roelofs, JL McCann… - MBio, 2019 - Am Soc Microbiol
ABSTRACT APOBEC3B is a single-stranded DNA cytosine deaminase with beneficial
innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by …
innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by …
Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer
A large number of DNA copy number alterations (CNAs) exist in human breast cancers, and
thus characterizing the most frequent CNAs is key to advancing therapeutics because it is …
thus characterizing the most frequent CNAs is key to advancing therapeutics because it is …
Introduction to molecular mechanisms in Notch signal transduction and disease pathogenesis
BD Giaimo, T Borggrefe - Molecular Mechanisms of Notch Signaling, 2018 - Springer
The Notch signaling pathway plays a pivotal role in development, physiology and diseases
such as cancer. In this chapter, we first give an overview of the different molecular …
such as cancer. In this chapter, we first give an overview of the different molecular …
NOTCH gene alterations in metastatic colorectal cancer in the Nationwide Cancer Genome Screening Project in Japan (SCRUM-Japan GI-SCREEN)
T Kajiwara, T Nishina, A Nakasya, N Yamashita… - Journal of Cancer …, 2022 - Springer
Abstract Purpose Activated Notch receptor signaling has been implicated in tumor growth
and progression in colorectal cancer (CRC). However, the pathogenic relevance of NOTCH …
and progression in colorectal cancer (CRC). However, the pathogenic relevance of NOTCH …