Our understanding of how the RAS protein family, and in particular mutant KRAS, promotes
metabolic dysregulation in cancer cells has advanced substantially over the last decade. In …

Autophagy is an intracellular self-degradative mechanism which responds to cellular
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Somatic mutations in the phosphatidylinositol/AKT/mTOR pathway cause segmental
overgrowth disorders. Diagnostic descriptors associated with PIK3CA mutations include …

The transcription factor GLI3 is a member of the Hedgehog (Hh/HH) signaling pathway that
can exist as a full length (Gli3-FL/GLI3-FL) or repressor (Gli3-R/GLI3-R) form. In response to …

Kras-activating mutations display the highest incidence in pancreatic ductal
adenocarcinoma. Pancreatic inflammation accelerates mutant Kras-driven tumorigenesis in …

Many researchers, especially those new to the field, need to determine which criteria are
essential for demonstrating autophagy, either for the purposes of their own research, or in …

Background: Platinum-based doublets with a third-generation agent are the recommended
option for many patients with non–small cell lung cancer (NSCLC) with no contraindications …

Hedgehog (Hh) pathway controls complex developmental processes in vertebrates.
Abnormal activation of Hh pathway is responsible for tumorigenesis and maintenance of …

Abstract The Vacuole Membrane Protein 1-VMP1-is a pancreatitis-associated
transmembrane protein whose expression triggers autophagy in several human diseases. In …