Caries and periodontitis are the two most common human dental diseases and are caused
by dysbiosis of oral flora. Although commensal microorganisms have been demonstrated to …

ABSTRACT Manganese (Mn2+) is an essential trace element within organisms spanning
the entire tree of life. In this review, we provide an overview of Mn2+ transport and the …

Metal ions provide considerable functionality across biological systems, and their utilization
within biomolecules has adapted through changes in the chemical environment to maintain …

Manganese (M n) is a required cofactor for all forms of life. Given the importance of M n to
bacteria, the host has devised strategies to sequester M n from invaders. In the macrophage …

In most organisms, transition metal ions are necessary cofactors of ribonucleotide reductase
(RNR), the enzyme responsible for biosynthesis of the 2′-deoxynucleotide building blocks …

Bacterial and fungal pathogens cause a variety of infectious diseases and constitute a
significant threat to public health. The human innate immune system represents the first line …

Manganese (Mn) is an essential micronutrient that is not readily available to pathogens
during infection due to an active host defense mechanism known as nutritional immunity. To …

All cells obtain 2′-deoxyribonucleotides for DNA synthesis through the activity of a
ribonucleotide reductase (RNR). The class I RNRs found in humans and pathogenic …

Streptococcus sanguinis is a common cause of infective endocarditis (IE). Efforts by
research groups are aimed at identifying and characterizing virulence factors that contribute …

Streptococcus sanguinis (S. sanguinis) is an abundant oral commensal which can cause
disseminated human infection if it gains access to the bloodstream. The most important …