The advent of modern C–H functionalization chemistries has enabled medicinal chemists to
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …

Conspectus Data science has revolutionized chemical research and continues to break
down barriers with new interdisciplinary studies. The introduction of computational models …

At the forefront of new synthetic endeavors, such as drug discovery or natural product
synthesis, large quantities of material are rarely available and timelines are tight. A …

The robust generation of quantum states in the presence of decoherence is a primary
challenge for explorations of quantum mechanics at larger scales. Using the mechanical …

Homogeneous catalysis has provided chemists with numerous transformations to enable
rapid construction of organic molecules. However, these reactions are complex, requiring …

High throughput experimentation has become widely used in the discovery and
development of new medicines. Progress in the field relies on an interplay between high …

Developing catalytic reactions for organic synthesis is the central goal of countless research
groups worldwide. High-throughput experimentation is invaluable for this pursuit, with the …

High-throughput (HT) techniques built upon laboratory automation technology and coupled
to statistical experimental design and parallel experimentation have enabled the …

This study focuses on building enantioselectivity models using only a few intuitively
meaningful descriptors based on the “buried volume” idea. Appropriate dissection of the …

Absolute rigidity is rare in the “soft” world of organometallics. Here we introduce two
cyclopenta [a] triptycyl ansa-zirconocene catalysts for isotactic-selective propene …