Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

Carbon-based nanozymes: Design, catalytic mechanism, and bioapplication

Y Sun, B Xu, X Pan, H Wang, Q Wu, S Li, B Jiang… - Coordination Chemistry …, 2023 - Elsevier
Carbon-based nanomaterials with enzyme-like activity are new candidates in materials
science. So far, various carbon-based nanozymes have been developed, such as …

Type I photosensitizers revitalizing photodynamic oncotherapy

D Chen, Q Xu, W Wang, J Shao, W Huang, X Dong - Small, 2021 - Wiley Online Library
Photodynamic therapy (PDT) has shown great potential for tumor treatment with merits of
non‐invasiveness, high selectivity, and minimal side effects. However, conventional type II …

[HTML][HTML] Oxidative stress–Complex pathological issues concerning the hallmark of cardiovascular and metabolic disorders

D Rotariu, EE Babes, DM Tit, M Moisi, C Bustea… - Biomedicine & …, 2022 - Elsevier
Oxidative stress is a complex biological process characterized by the excessive production
of reactive oxygen species (ROS) that act as destroyers of the REDOX balance in the body …

Nanozymes: classification, catalytic mechanisms, activity regulation, and applications

Y Huang, J Ren, X Qu - Chemical reviews, 2019 - ACS Publications
Because of the high catalytic activities and substrate specificity, natural enzymes have been
widely used in industrial, medical, and biological fields, etc. Although promising, they often …

[HTML][HTML] Therapeutic potentials of superoxide dismutase

H Younus - International journal of health sciences, 2018 - ncbi.nlm.nih.gov
Superoxide dismutases (SODs) constitute a very important antioxidant defense against
oxidative stress in the body. The enzyme acts as a good therapeutic agent against reactive …

A Redox Modulatory Mn3O4 Nanozyme with Multi‐Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model

N Singh, MA Savanur, S Srivastava… - Angewandte …, 2017 - Wiley Online Library
Nanomaterials with enzyme‐like activities (nanozymes) attracts significant interest due to
their therapeutic potential for the treatment of various diseases. Herein, we report that a …

Superoxide dismutase administration: A review of proposed human uses

AC Rosa, D Corsi, N Cavi, N Bruni, F Dosio - Molecules, 2021 - mdpi.com
Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant
defense against oxidative stress in the body. SOD supplementation may therefore trigger the …

Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes

H Wei, E Wang - Chemical Society Reviews, 2013 - pubs.rsc.org
Over the past few decades, researchers have established artificial enzymes as highly stable
and low-cost alternatives to natural enzymes in a wide range of applications. A variety of …

Metallodrugs in medicinal inorganic chemistry

KD Mjos, C Orvig - Chemical reviews, 2014 - ACS Publications
Metal ions play important roles in biological processes, 1 and the field of knowledge
concerned with the application of inorganic chemistry to therapy or diagnosis of disease is …